Obesity Drug ‘Mediator’ Likely Responsible For Thousands Of Hospitalizations And Deaths In France

This caption falls under a late-night comedy show like Letterman’s Top Ten of the wrong name to use for a drug.  I am a MEDIATOR (and Farmers Agent) and I know that a mediator could not be responsible for thousands of hospitalizations.  Just some light humor for Friday.  Here is the article:

A new study published in the journal Pharmacoepidemiology & Drug Safety reveals that benfluorex, a fenfluramine derivative drug used in France under the name Mediator®, is likely responsible for thousands of hospitalizations and deaths over a 30 year period.

Benfluorex (Mediator®) was used in France from 1976 to 2009. Despite its anorexic properties, the drug was not marketed as an appetite suppressant but as an adjunct for the treatment of hyperlipidemia and among overweight patients with type 2 diabetes.

Mahmoud Zureik, MD, PhD, of the French National Institute of Health and Medical Research, and colleagues utilized existing data on benfluorex exposure in France, the risk of actual hospitalization for valvular insufficiency, and mortality from vascular insufficiency as a basis for detailed calculations.

Results show that the use of benfluorex during the period 1976-2009 was very likely responsible for around 3,100 hospitalizations and 1,300 deaths due to valvular insufficiency.

“Despite its similarity with the two appetite suppressants fenfluramine and dexfenfluramine, benfluorex was kept on the market for more than 30 years in France,” Zureik notes. “French citizens, practitioners, politicians, and public health actors were seeking to understand why the French health products safety agency took so long to withdraw this drug which was of very limited efficacy and was dangerous.” Because of this scandal, a new law has been passed that substantially modifies the regulatory system for drugs in France.

  1. Leave a comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

<span>%d</span> bloggers like this: